BeFisetinTM Features

BeFisetinTM is produced under a full set of industry management to ensure the quality, safety, and efficacy of products. BeFisetin aims to be the leading standard of fisetin on the market. Making it a quality-traceable, high-standard, science-based fisetin.

Maximize the utilization of raw ingredients

High-quality raw materials are the basics for qualified end products. Bonerge acquires these natural plants from special places of production in certain seasons.

To select the right plant source for Fisetin extraction, we retrieved and studied the literature thoroughly. Rhus Cotinus L. (Smoketree) is the most studied source for Fisetin. What a coincidence, it has a long history of traditional medical use in China and Europe. The long-lasting and consistent use of C. coggygria in traditional medicine across countries offers a sound base for its therapeutic use.

Although the traditionally used part of smoketree is its trunk, we conducted a series of studies to extract Fisetin from leaves and branches since sustainable and eco-friendly development is Bonerge’s commitment.  

Ultra Efficient Continuous Countercurrent Extraction technique

A continuous extraction approach (though sometimes performed in a batch-wise manner) is countercurrent extraction. In countercurrent extraction, both phases are continuously added (or changed) and flow in opposite directions as the extraction progresses

Our facility is equipped with two continuous countercurrent extraction lines, and each line is available in capacities of up to 20-30 tons/day of raw material. Enable us to get the best quality at the best cost.

Health-oriented production without inedible solvents application

The manucaturing of BeFisetin is without harmful solvent, like methanol and acetone, to ensure the safety of our products and sustainability of environment.

Bonerge cares for the nature and environment, methanol is not used during the whole process thus the most natural ingredients were extracted with water. No organic solvent waste will go into the environment from Bonerge’s factory. It’s been the traditional way for thousands of years and human beings have lived in harmony with nature.

Bonerge cares for its employees, none of its employees will be exposed to harmful chemicals in the factory. Even though the residual solvent could be removed from the end products to some extent, the employees are still exposed to methanol solvents during the process.

A Full set Basic Quality Research

How do you know the product you get is what you need? – HPLC is not enough.

With professional analytical scientists and advanced equipment, top quality and consistency among batches are the golden promises to our customers from Bonerge. The identity test, purity test, impurity test, and assay test that are usually applied in the pharmaceutical industry and guided by USP requirements, is at the center of Bonerge’s quality research.  LC-MS, IR, HNMR, CNMR are applied to confirm the molecular weight and the chemical structure of BeFisetin.

Trusted Reference Standard

Purity focuses on the active component, HPLC is the most common test for this item. In this test, the total detected area is normalized to 100% and the portion of the detected area of the main peak(TDA%) stands for the purity of the ingredient. No external standard is required.

Unlike the purity test, Reference Standard(RS) is used as an external standard in the assay. Assay is usually more reliable than purity to judge the quality of a dietary ingredient. An RS will directly influence the results but it’s hard to apply an RS when a compendial RS from USP, or EP is not available.

A trusted RS is like an impartial judge. While some suppliers use purity to mislead consumers intentionally, their Fisetin touted 98% purity might be less than 80% in assay.

Reference substances are of great importance for a test method. However, no such official RS is available from USP or EP. Bonerge sourced Fisetin RS globally and finally chose a reputable German Reference Standard from Sigma as its external standard.

High-standard production environment

Bonerge is one branch company developed from Delore Group company, our newly constructed state-of-the-art 70,000 square meters manufacturing facility located in Yongzhou city. We are proud to hold and maintain a full set of the most important world-class manufacturing quality certifications including cGMP, GMP+, FSSC22000, HACCP, ISO22000, Halal, Kosher, USDA Organic, Ecocert Organic Standard. We always go the extra mile to give you the assurance that our BeFisetin is of utmost quality, safety, and function.

Our facility incorporates separate authorized areas for handling plant extract, organic fruit & vegetable powder, food additive,  feed material , where the Quality System ensures compliance with GMP, Hazard Analysis and Critical Control Points guidelines.

Every product available through Bonerge was manufactured at our certified state-of-the-art facilities, each has been thoroughly lab tested and manufactured subject to rigid quality control guidelines.

Advanced Analytical Instruments

To keep top quality and consistency among batches of our products, we conduct tests for every batch of the products both in-house and in the third laboratories for identity, purity, assay, microbiology, heavy metals, pesticides, and solvent residue when applicable. Our testing lab has been certified by CNAS and CMS bodies, Following compendial analytical guidelines,  we employ high-performance analytical tools (such as HPLC, HPLC-MS, GC, GC-MS, PPSL, NMR, ICP, TLC, and FTIR to ensure total quality.

Analytical Procedure Life Cycle management, usually applied in the pharmaceutical industry and guided by UPS requirements, is at the center of BongeLov’s testing system.

Analytical Procedure Life Cycle Management

• Analytical Method Design

• Analytical Method Development

• Analytical Method Validation

• Analytical Method Transfer

• Analytical Method Verification

BongeLov System Guaranteed

Bonerge is aiming to offer premium-quality ingredients with potent healthy values to the world. Following the scientific practice of evidence-based nutrition and evidence-based medicine, our team launched BongeLov Management System,BongeLov is representing our determination of uncompromising research on product Safety, Quality, and Potency.

Scroll to Top
Verified by MonsterInsights