What is Fisetin?

What is Fisetin?

We all know – one cup of fruits and vegetables every day, for our health. But what actually makes them good for our bodies?

Well, fruits and vegetables are rich in flavonoids. 
Fisetin is one of the most deeply investigated flavonoid that  found in trace amounts in various fruits and vegetables, such as strawberries, persimmons, apples, grapes, onions, kiwi, kale, etc, but the amount of fisetin in these foods is insufficient.
The estimated daily intake of fisetin in Japan is 0.4 mg per day while the daily recommended dosage for fisetin as a dietary supplement is 100 mg per day according to exist studies.

Molecular information of Fisetin
CAS Registration No.528-48-3
Formal Name2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
MFC15H10O6
FW286.2
SolubilityEthanol: 5 mg/ml DMSO/DMF: 30 mg/ml

History of Fisetin

The first record of fisetin as an isolate from Rhus cotinus L. dates back to 1833. A basic chemical characteristics of the compound was provided later by Schmidt in 1886, while its structure was elucidated and eventually confirmed by synthesis by S. Kostanecki in 1890s.

Fisetin has by now been identified as an important secondary metabolite of many plants, shares a distinct antioxidating activity which was confirmed by various in vitro as well as in vivo models since the 20th century.
Preclinical and some preliminary clinical studies suggest that fisetin protect against age-related disorders (Inflammation, Osteoporosis, Alzheimer’s, Cognitive Disorder, Stroke and so on ), slow aging process and promote longevity.


What is BeFisetin?

To select the right plant source for Fisetin extraction, we retrieved and studied the literature thoroughly. Rhus cotinus L.(Smoketree) is the most studied source for Fisetin. Smoketree grows widely in Asia and Europe but the traditionally used part is its trunk. However, sustainable and eco-friendly development is Bonerge’s commitment. Bonerge conducted a series of studies to extract Fisetin from leaves and branches instead of trunks.

After purified Fisetin from the plant, The most comprehensive analysis method such as LC-MS, IR, NMR, XRD,TGA, HPLC etc are applied to confirm you get the real and pure Fisetin from BeFisetin.

Of course, the most important part is assay analysis, because assay is more reliable to judge the quality of a dietary ingredient than purity.

Bonerge sourced Fisetin RS globally since there is no official RS available for assay analysis. Finally we choosed a reputable German Standard from Sigma as external standard. A trusted RS is like an impartial judge. While some suppliers use purity to mislead consumers intentionally, their Fisetin touted 98% purity might be less than 80% in assay.

Following compendial guidelines, Bonerge develops Befisetin™.

With its slogan to be the standard of Fisetin, Befisetin™ will always be on the way to a higher standard of Fisetin.

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