BeFisetin Ultra99 is extracted from Rhus succedanea (wax tree). Some common food sources are strawberries, apples, green tea. Although Fisetin is a naturally occurring flavonoid, it is difficult to achieve an effective level from our daily diet.

The potency of Fisetin depends on the content level, rather than the raw material.

We use HPLC for the testing. To measure the accurate assay of BeFisetin, we use German reference samples from Sigma after a careful process of comparing.

BeFisetin Ultrapure99 contains total flavonoids greater than 99%, Fisetin content greater than 98%, and total impurities smaller than 1%.

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Dietary use:
The health benefits of Fisetin make it a promising raw ingredients for dietary supplements. The key health benefit of fisetin is the senolytics effect. It allows our body to get rid of old and damaged cells.
Pharmaceutical use:
The accumulation of senescent cells causes inflammation in surrounding cells and chronic conditions. The natural properties of fisetin might help combat different conditons, especially age-related health problems.
Cosmeceutical use:
With age, senescent cells accumulation in the skin can result in decreased thickness and regenerative capacity. Removing senescent cells via fisetin can help the absorption of nutrients.

Yes, BeFisetin is Kosher and Halal certified.

Yes, it is. It is also free of most known allergens. Contact us to get the latest certifications and allergen statements.

We have heavy metal, microbiome, and solvent residue reports from a trusted third-party lab. Please email us for details.

Production: We aim to enhance production efficiency and reduce production costs.
Scientific Research: We have designed and conducted in vitro and animal studies to investigate the efficacy and mechanisms of fisetin. Additionally, we have carried out clinical trials to assess the safety of fisetin.
Quality: To ensure our BeFisetin is Fisetin, we went through a strict testing method validation process.

It is grown in China for landscape plants. We use the leaves and branches of trees so it will keep growing. We also cooperate with the largest Toxicodendron succedaneum L.(syn: Rhus succedanea) plantation in China for sustainable farming and upcycling the waste from harvesting.

Cell anti-aging, healthy metabolism, hair-loss prevention, brain fog clearance etc.

- Fisetin clears senescent cells and senescence-associated secretory phenotypes (SASP), and has been shown to be one of the most effective senolytic agents from plant sources.
- It mimics the effects of fasting, promotes cellular autophagy, and increases levels of AMPK and SIRT1 in the body.
- It inhibits mTOR.
- It maintains levels of glutathione (GSH), eliminates free radicals, and preserves youthful vitality.

Cellular senescence can be caused by a variety of stresses including but not limited to telomere shortening, oncogene activation and the presence of reactive oxygen species. Among them, telomere shortening represents one of the most important. The Hayflick limit states that as cell divisions increase, telomeric DNA gradually shortens, eventually leading to cell cycle arrest and entry into a senescent state. Additionally, common factors such as environmental influences, lifestyle choices, drug usage, physiological and pathological contexts can also accelerate cellular aging. Since cellular senescence is a multifaced result, it is important to introduce senolytics when needed.

Senescent cells are not characterized by universal or specific biomarkers, but rather by a number of nonexclusive markers. Such as:
1) an altered cell size with a more smoothed shape compared with proliferating cells and exhibit senescence-associated heterochromatin foci formation,
2) a higher activity of senescence-associated β-galactosidase (SA-β-gal),
3) augmented level of cell cycle inhibitors, including p16INK4a, p21CIP1, and p27.
4) accumulation of lipofuscin.
5) DNA damage foci,
6) loss of Lamin B1,
7) secretion of a large number of factors, including growth factors, cytokines, chemokines, and proteases, known as the senescence-associated secretory phenotype (SASP) or senescence-messaging secretome.

Senescent cells can accumulate with age and at sites of age-related pathologies, such as in osteoarthritis and atherosclerosis, and can have an impact on the normal physiology of the tissues, causing a progressive functional deterioration.

StanYouth is extracted from Rhus Cotinus L. (Smoketree). Some common food sources are strawberries, apples, green tea. Although Fisetin is a naturally occurring flavonoid, it is difficult to achieve an effective level from our daily diet.

Typically, the inflammation produced by aging cells is sufficient to activate the immune system to clear aging cells within days or weeks. However, according to the threshold theory of senescent cell burden, once the abundance of aging cells reaches a threshold, the immune system cannot keep up with clearing them. In turn, immune system cells also become senescent, further exacerbating the accumulation of aging cells. These continuously accumulating aging cells gradually lose vitality and function, causing tissue and organ degeneration at the macroscopic level, ultimately leading to the appearance of various forms of diseases and aging.

In recent years, researchers have found several methods to eliminate senescent cells, one of which is through drug-based targeted killing of these cells, a therapeutic approach known as “Senotherapeutics”. The drugs used in this treatment are called senolytics. Application of senolytics in mouse disease models has shown improvement in conditions such as atherosclerosis, osteoarthritis, cataracts, tumorigenesis, cardiac hypertrophy, renal dysfunction, lipid metabolism disorders, and sarcopenia.

Mechanism: Induce senescent cell apoptosis and inhibit SASP release.
Fisetin has been shown to improve various age-related diseases and symptoms by targeting and removing senescent cells. Studies have demonstrated that fisetin, as a senolytic, can extend the average lifespan of mice, while also helping to alleviate fibrosis in the lungs and kidneys, preserve the differentiation capacity of stem cells, and enhance skeletal and muscle function.

On one hand, fisetin, extracted from plants, is a natural bioactive compound commonly used as a dietary supplement, as opposed to synthetic drugs like dasatinib and navitoclax (ABT263). Furthermore, both cellular and animal studies have not reported any adverse effects of fisetin, and no detrimental impacts on human subjects have been observed in the completion of four clinical trials involving fisetin.

On the other hand, fisetin exhibits a significantly superior capacity to eliminate senescent cells compared to other naturally derived constituents such as quercetin, resveratrol, and more. These pieces of evidence thoroughly demonstrate the potential and wide applicability of fisetin as a senolytic

Sirtuins are a group of proteins that play a role in regulating cellular health and longevity. There are seven sirtuins in mammals, with SIRT1, SIRT3, and SIRT6 being considered anti-aging molecules. Activation of sirtuins, particularly SIRT1 and SIRT6, has been associated with cardioprotective, anti-inflammatory, anti-atherosclerosis, and anti-aging properties. Fisetin has been suggested that it may activate sirtuins. More studies are needed to fully understand the potential of Fisetin in activating sirtuins and its implications for anti-aging effects.

Research has shown that sirtuins delay cellular aging and increase organismal lifespan by regulating various cellular activities. In particular, in silico and in vitro studies have elucidated the potential of certain compounds, such as resveratrol, to activate sirtuins and exert anti-aging effects. Additionally, nicotinamide mononucleotide (NMN) has been studied for its role in increasing NAD+ levels, which can activate sirtuins and potentially impact aging-related conditions.

Caloric restriction (CR) is a dietary regimen that reduces calorie intake without causing malnutrition. It has been linked to anti-aging effects, as studies have shown that CR can extend lifespan and improve health in various organisms, including mammals. The link between caloric restriction and anti-aging is thought to be mediated by its effects on cellular processes, such as reducing oxidative stress, enhancing DNA repair, and improving metabolic function. Caloric restriction has been a focus of research in the field of aging and longevity, and it is considered one of the most robust interventions for extending lifespan and delaying the onset of age-related diseases.

Caloric restriction mimetics are compounds that produce beneficial effects on health and longevity similar to those of caloric restriction, without the need to reduce calorie intake. These mimetics work by activating cellular pathways that are also influenced by caloric restriction, such as autophagy and stress response mechanisms. Fisetin has been suggested that it may mimic some of the effects of caloric restriction. Research has shown that Fisetin can activate sirtuins, which are involved in the cellular response to caloric restriction and have been linked to anti-aging effects.

The blood-brain barrier (BBB) is a highly selective barrier that separates the circulating blood from the brain's extracellular fluid, protecting the brain from potentially harmful substances. Fisetin's ability to cross this barrier is crucial for its potential neuroprotective effects.
1）Orally administered fisetin crosses the blood-brain barrier and promotes synaptic functions in the hippocampus.
2）Fisetin's BBB permeability has been reported in several studies, including its high brain uptake potential in vitro and its distribution to the blood vessels of the brain after intraperitoneal injection and oral administration in mice.
In addition to its ability to cross the blood-brain barrier, fisetin has been indicated to regulate key neurotrophic factor-induced signaling pathways and act as a promising neuroprotective compound, preventing cell death and oxidative stress-mediated damage.

The hallmarks of aging refer to interconnected key biological processes that contribute to the aging of organisms. These hallmarks are crucial for understanding how and why aging occurs, and they provide potential targets for interventions aimed at promoting healthy aging and extending lifespan. Originally, nine hallmarks were proposed in 2013, but more recently, this list has been expanded to twelve. The most commonly accepted hallmarks of aging include:
a) Genomic Instability: Accumulation of DNA damage over time due to environmental and endogenous factors leads to genomic instability, contributing to the aging process.
b) Telomere Attrition: Telomeres, the protective ends of chromosomes, shorten with each cell division, eventually leading to cellular senescence or apoptosis when they become critically short.
c) Epigenetic Alterations: Changes in DNA methylation, histone modification, and chromatin remodeling affect gene expression and cellular function as organisms age.
d) Loss of Proteostasis: The decline in the ability of cells to maintain protein homeostasis results in the accumulation of damaged or misfolded proteins, which can lead to cellular dysfunction and diseases such as Alzheimer's.
e) Deregulated Nutrient Sensing: Alterations in nutrient-sensing pathways, such as insulin/IGF-1 signaling, mTOR, AMPK, and sirtuins, affect metabolism and can accelerate aging.
f) Mitochondrial Dysfunction: Mitochondria, the powerhouses of the cell, become less efficient and generate more reactive oxygen species (ROS) with age, contributing to cellular damage and energy production decline.
g) Cellular Senescence: Cells permanently stop dividing and enter a state of senescence in response to various stressors. Senescent cells can secrete pro-inflammatory factors that affect tissue function.
h) Stem Cell Exhaustion: The regenerative capacity of tissues declines with age due to the depletion and dysfunction of stem cells, leading to impaired tissue repair and maintenance.
i) Altered Intercellular Communication: Aging affects the communication between cells, leading to chronic inflammation and changes in hormonal signaling, which can negatively impact tissue function and homeostasis.
j) Impaired Autophagy: Reduced efficiency of the autophagy process, which is responsible for removing damaged cellular components.
k) Microbiome Dysbiosis: Imbalance in the gut microbiome that affects metabolism, immunity, and inflammation.
l) Chronic Inflammation: Persistent low-level inflammation that contributes to the progression of age-related diseases.
These hallmarks are interconnected and often influence each other, creating a complex network of processes that drive aging. Understanding these mechanisms offers pathways for developing interventions to mitigate the effects of aging and promote longevity.

The recommended dosage for fisetin is 100-500mg per day. If you have any health-related concerns, please advise a health practitioner.
The range for most fisetin supplements is 100-500 mg per day.
In a clinical trial involving colon cancer patients, 100 mg per day was effective in reducing inflammation.
In ongoing clinical trials involving fisetin, most doses are around 20 mg/kg per day.

Senescent cells accumulate with age, inflammations and damage from the environment can stimulate the accumulation. You can take BeFisetin daily or intermittently with a higher dose for its hit-and-run mechanism.

There is currently no available information to assess whether fisetin affects normal cells when it induces apoptosis in aging cells. However, fisetin has been shown to have anti-inflammatory and antioxidant properties, which may help protect normal cells from damage.

It is recommended that pregnant and breastfeeding women consult a doctor before taking any dietary supplements. Although a literature review suggests that fisetin is safe to take during pregnancy with no side effects, this evidence is not sufficient to support its use during pregnancy.

According to existing studies, fisetin is generally safe for most people, even at high doses, with no reported side effects.

The key equipment we are using is continuous counter-current extraction equipment. .The high-efficiency equipment saved about 70% production time and solvent with 10 times more output than traditional extraction tank. Less input means less ecological footprint.

ISO 22000, GMP+, HACCP, ISO9001, HALAL, KOSHER

Continuous counter-current extraction equipment is the ultra-efficiency, massive production unit that often used for many many health and herbal products.
In countercurrent extraction, both the solid feed and solvent are continuously added and flow in opposite directions as the extraction progresses. During the process, the solid feed is repeatedly contacted or washed with extracting solvent, resulting in an effective output.